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Two of the most anticipated studies this year—large-scale, randomized, controlled, and double-blinded trials of the popular obesity and diabetes drug semaglutide for Alzheimer's disease—have unfortunately ended in a dud. An oral version
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Associations of semaglutide with first‐time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real‐world data in the US - Wang - 2024
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Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid models
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GLP-1 Drug Fails to Quell Alzheimer's in Novo Nordisk Trials
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A 2024 Alzheimer's & Dementia study of 1,094,761 type-2 diabetics showed semaglutide cut first-time Alzheimer's diagnoses by ~70% versus conventional antidiabetics. (Wang et al.) We used to talk about GLP-1 agonism as
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Focus: After weight loss, Alzheimer's may be next frontier for drugs like Ozempic
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Semaglutide fails to slow progression of Alzheimer's in highly anticipated trials, Novo Nordisk says
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