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triple agonist glp-1 Retatrutide is a triple-agonist drug targeting GLP-1, GIP, and glucagon receptors to suppress appetite and boost thermogenesis. Phase 2 trials reported 24.2% average weight loss and over 80% liver fat reduction, reversing

Marsoni M251S
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GLP 1 Drugs: Bridging Satiety, Nutrition, and Innovation Kerry Health And Nutrition Institute UBT251 vs Retatrutide: The New Triple Agonist Peptide Entering the GLP 1 Arms Race Xcel Peptides GLP 1 Receptor Agonists as Treatments for Type 2 Diabetes MedRAC@UNC Orforglipron, an Oral Small Molecule GLP 1 Receptor Agonist for Obesity November 5, 2025 DOI: 10.1056 NEJMdo008238 New for the treatment of obesity and so many additional indications being studied orforglipron. What have Strategies for minimizing muscle loss during use of incretinmimetic drugs for treatment of obesity Mechanick 2025 Obesity Reviews Wiley Online Library
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4.8 ★★★★★
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Random shopper
Belleville, US
★★★★★ 1
Rope comes out at the slightest force. Pointless tug toy!
Color: Four colors, Size: 6cm (with rope)
If your dog pulls on these (and why wouldn’t he?), the rope immediately comes out. Turns out they just fuse the ends of the nylon rope together, which is no match for a dog playing tug. Any dog, any level of pulling will dismantle these. We’ve managed to reinsert the rope to a couple of these and KNOT it, which gives you a shorter rope but a toy that can withstand some play. But if I had wanted a DIY toy, I’d have used the balls and rope I already own.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 11, 2025
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Verified Purchase
Lesly
Los Angeles, US
★★★★★ 3
Not for super chewers!
Color: Four colors, Size: 5cm (with rope), Color: Four colors, Size: 5cm (with rope)
These rope ball toys arrived today. My poodle puppy loves rope ball toys and playing tug of war. These didn’t last 10 minutes. For context, she is 1 y.o., 30 lbs., is not teething & has her adult teeth. She did this on her own- we were not playing tug of war at the time the toy fell apart. At least there are 3 more in the package & when the rope is done, we’ll still have the balls to play with.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 15, 2026
K
Verified Purchase
Kimberly Farnham
Carnegie, US
★★★★★ 4
Great for small dogs
Color: Four colors, Size: 5cm (ball only)
Durability
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Reviewed in the United States on February 28, 2026
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Verified Purchase
Janet
Houston, US
★★★★★ 5
Great toy
One of the best dog toys ever! Well made & sturdy enough to withstand hrs of play & tug between my Lab & my Westie.
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Reviewed in the United States on May 6, 2026
K
Verified Purchase
karen
Draper, US
★★★★★ 5
Extremely Durable for Large Dogs
Great for a dog who loves balls. Extremely durable for my the dogs, each over 100#!
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Reviewed in the United States on April 28, 2026

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